In 2000, science-based risk analysis was performed by Cantox Health Sciences International, a world-renowned, independent scientific consulting firm. Cantox assessed all available scientific information—focusing on 19 clinical trials, including the critical data from the Harvard and Columbia trial that found ephedra both safe and beneficial for weight loss at the 90mg per day dosage, as well as other key data including adverse event reports (AERs) collected by the Food and Drug Administration (FDA).

Safety Assessment and Determination of a Tolerable Upper Limit for Ephedra (All materials copyright CRN.)

• Abstract

• Executive Overview

• Complete Cantox Report Download the entire report (Read-only MS Word document)

• Appendices (The Cantox report has 3 appendices, Appendix A has 6 Annexes) • Appendix A —AERs (Read-only MS Word document) • Annex 1, 3—6 (Access databases) • Annex 2 (Read-only MS Word document) • Appendix B—Case Reports (Read-only MS Word document) • Appendix C—Columbia-Harvard Abstract & Analysis Sheet (Read-only MS Word document)