Vitamin & Mineral Safety

Introducing New Updated Chapters in the Vitamin and Mineral Safety Handbook!

We’re thrilled to announce the release of updated chapters for the Vitamin and Mineral Safety: 4th Edition. These updates reflect the latest scientific research and reaffirm our commitment to transparency and science-driven resources for the dietary supplement industry.

What’s New?

The latest edition incorporates a modernized methodology for identifying, screening, and evaluating data:

Biotin [PDF]
Calcium [PDF]
Choline and Citicoline [PDF]
Folic Acid and Methylfolate [PDF]
Iron [PDF]
Lutein, Zeaxanthin, and Meso-Zeaxanthin [PDF]
Magnesium [PDF]
Potassium [PDF]
Selenium [PDF]
Vitamin A [PDF]
Vitamin B3 [PDF] (including nicotinic acid, nicotinamide, nicotinamide riboside, inositol hexanicotinate)
Vitamin B6 [PDF]
Vitamin E [PDF]
Vitamin K2 [PDF]
Zinc [PDF]

These updates have been meticulously completed by ToxStrategies, leveraging new technologies to ensure the handbook remains a trusted resource for evaluating nutrient safety. Want to know more about the methodology used? Check out the revised Methodology chapter here: [PDF].

These chapters are provided for informational and scientific discussion purposes only and are not intended to constitute medical advice, diagnosis, or treatment recommendations. The information presented does not establish formulation standards, recommended dosages, or intake limits, and should not be relied upon for legal, regulatory or compliance purposes. Nothing in these materials is intended to replace applicable legal, regulatory, or professional requirements, which may vary by jurisdiction. Readers should consult qualified healthcare professionals and appropriate legal and regulatory advisors before making decisions related to nutrient supplementation, regulatory compliance, or formulation standards.

We need your support! Funding is provided through a grant from the CRN Foundation, supported by tax-deductible member donations. Interested members should contact Andrea Wong (awong@crnusa.org).

PAST INFORMATION

This handbook provides valuable science-based recommendations for establishing Tolerable Upper Intake Levels (ULs) for supplemental sources of these nutrients—a trusted resource for dietary supplement and dietary ingredient manufacturers, as well as scientific bodies and regulatory policy makers worldwide. Read more in CRN's archived 2014 press release.

Download full book (2014 edition)

Download individual chapters (2014 edition)